THE CHOSEN: A new study finds that neurons compete to be in the lucky 20 percent that make a memory during learning or training activities.
Image: © ISTOCKPHOTO/SEBASTIAN KAULITZKI
The Brain May Use Only 20 Percent of Its Memory-Forming NeuronsStudy shows that that pace at which a brain cell activates a key protein may influence its role in memory formation—a finding that could lead to new Alzheimer therapies
By Nikhil Swaminathan @ Scientific American
Remember the old myth that people only use 10 percent of their brains? Although a new study confirmed that bromide to be apocryphal, it did find that we may only use 20 percent of the nerve cells in our midbrain to form memories.
Researchers at the University of California, Los Angeles, and The Hospital for Sick Children in Toronto monitored neurons in the lateral amygdalae (two almond-shaped regions on either side of the midbrain associated with learning and memory) of mice to see whether the presence of the CREB (cAMP response element binding) protein plays a key role in signaling brain cells to make memories.
CREB, a transcription factor that typically increases the production of other proteins in cells, is believed to be involved in memory formation in organisms from sea slugs to humans. Scientists hope that their findings, reported in the current issue of Science, may help pave the way to new treatments for Alzheimer's Disease.
In the future, Josselyn says, this mechanism could be harnessed to produce a new treatment for Alzheimer's disease. "In time, we're going to have some sort of neuron-replacement therapy for Alzheimer's," she says, conceding, "It's a little sci-fi right now." But, if new neurons are inserted into a damaged brain, modulating CREB function could help bias the healing brain to use the functioning neurons and not its injured population.
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